线虫感知行为的研究进展

doi:10.11843/j.issn.0366-6964.2016.05.001

摘要/Abstract

摘要：

寄生性线虫寄生于动植物中，给人类健康和动植物生产带来了巨大危害。线虫的感受系统能准确地感知外界信息，从而调节个体及时躲避危险、趋近适宜环境，这为线虫的生存繁衍提供重要保障。研究发现，线虫的感知行为存在于其各种生命活动中（如觅食、寻找宿主、交配等），并且这种行为具有很强的特点和规律性。作者总结了线虫感知能力对其行为影响的研究进展，旨在帮助读者了解本领域的研究现状和研究前景，为寄生性线虫的防治和新型药物的研发提供参考。

Abstract:

Parasitic nematodes cause serious public health problems and significant economic loss in animal husbandry industry.With the help of accurate sensory system，parasitic nematodes are able to avoid dangerous and adapt to the environment.The distinctive sensory behaviors are found to be involved in all kinds of nematodes life activities (e.g.foraging，host seeking，mating，etc.).Here，we summarized the research status and progress of chemosensory behaviors of nematodes.These may help shed light on the development of novel intervention strategies.

中图分类号:

S852.731

郑友乐，王承东，汪涛. 线虫感知行为的研究进展[J]. 畜牧兽医学报, 2016, 47(5): 857-863.

ZHENG You-le，WANG Cheng-dong，WANG Tao. Research Advances on Chemosensory Behaviors of Nematodes[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(5): 857-863.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: https://www.xmsyxb.com/CN/10.11843/j.issn.0366-6964.2016.05.001

https://www.xmsyxb.com/CN/Y2016/V47/I5/857

参考文献

［1］BAE Y K，BARR M M. Sensory roles of neuronal cilia：Cilia development，morphogenesis，and function in C. elegans［J］. Front Biosci，2008，13：5959-5974.
［2］WHO. 2015，Available from：http://www.who.int/mediacentre/factsheets/fs366/en/.
［3］CHINTOAN-UTA C，MORGAN E R，SKUCE P J，et al. Wild deer as potential vectors of anthelmintic-resistant abomasal nematodes between cattle and sheep farms［J］. Proc Biol Sci，2014，281(1780)：20132985.
［4］RAZA A，KOPP S R，JABBAR A，et al. Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro［J］. Vet Parasitol，2015，211(1-2)：80-88.
［5］GEARY T G. Ivermectin 20 years on：maturation of a wonder drug［J］. Trends Parasitol，2005，21(11)：530-532.
［6］HALLEM E A，STERNBERG P W. Acute carbon dioxide avoidance in Caenorhabditis elegans［J］. Proc Natl Acad Sci U S A，2008，105(23)：8038-8043.
［7］HALLEM E A，SPENCER W C，MCWHIRTER R D，et al. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans［J］.Proc Natl Acad Sci U S A，2011，108(1)：254-259.
［8］LAZNIK Z，TRDAN S. An investigation on the chemotactic responses of different entomopathogenic nematode strains to mechanically damaged maize root volatile compounds［J］. Exp Parasitol，2013，134(3)：349-355.
［9］CHAISSON K E，HALLEM E A. Chemosensory behaviors of parasites［J］.Trends Parasitol，2012，28(10)：427-436.
［10］BUMBARGER D J，WIJERATNE S，CARTER C，et al. Three-dimensional reconstruction of the amphid sensilla in the microbial feeding nematode，Acrobeles complexus (Nematoda：Rhabditida)［J］. J Comp Neurol，2009，512(2)：271-281.
［11］CARRILLO M A，HALLEM E A. Gas sensing in nematodes［J］.Mol Neurobiol，2015，51(3)：919-931.
［12］RASMANN S，ALI J G，HELDER J，et al. Ecology and evolution of soil nematode chemotaxis［J］. J Chen Ecol，2012，38(6)：615-628.
［13］APPLEBY P A. A model of chemotaxis and associative learning in C. elegans［J］. Biol Cybern，2012，106(6-7)：373-387.
［14］SRINIVASAN J，DURAK O，STERNBERG P W. Evolution of a polymodal sensory response network［J］. BMC Biol，2008，6：52.
［15］BRETSCHER A J，KODAMA-NAMBA E，BUSCH K E，et al. Temperature，oxygen，and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior［J］. Neuron，2011，69(6)：1099-1113.
［16］FENK L A，DE BONO M. Environmental CO₂ inhibits Caenorhabditis elegans egg-laying by modulating olfactory neurons and evokes widespread changes in neural activity［J］. Proc Natl Acad Sci U S A，2015，112(27)：E3525-E3534.
［17］SCOTT K. Out of thin air：sensory detection of oxygen and carbon dioxide［J］. Neuron，2011，69(2)：194-202.
［18］BRETSCHER A J，BUSCH K E，DE BONO M. A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans［J］. Proc Natl Acad Sci U S A，2008，105(23)：8044-8049.
［19］GRAY J M，KAROW D S，LU H，et al. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue［J］. Nature，2004，430(6997)：317-322.
［20］MATSUURA T，MIURA H，NISHINO A. Inhibition of gustatory plasticity due to acute nicotine exposure in the nematode Caenorhabditis elegans［J］. Neurosci Res，2013，77(3)：155-161.
［21］ILAN T，KIM-SHAPIRO D B，BOCK C H，et al. Magnetic and electric fields induce directional responses in Steinernema carpocapsae［J］.Int J Parasitol，2013，43(10)：781-784.
［22］SHAPIRO-ILAN D I，LEWIS E E，CAMPBELL J F，et al. Directional movement of entomopathogenic nematodes in response to electrical field：effects of species，magnitude of voltage，and infective juvenile age［J］. J Invertebr Pathol，2012，109(1)：34-40.
［23］ZHANG Y. Neuronal mechanisms of Caenorhabditis elegans and pathogenic bacteria interactions［J］. Curr Opin Microbiol，2008，11(3)：257-261.
［24］SAWIN E R，RANGANATHAN R，HORVITZ H R. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway［J］. Neuron，2000，26(3)：619-631.
［25］ASHTON F T，ZHU X，BOSTON R，et al. Strongyloides stercoralis：Amphidial neuron pair ASJ triggers significant resumption of development by infective larvae under host-mimicking in vitro conditions［J］. Exp Parasitol，2007，115(1)：92-97.
［26］LI J，ZHU X，BOSTON R，et al. Thermotaxis and thermosensory neurons in infective larvae of Haemonchus contortus，a passively ingested nematode parasite［J］. J Comp Neurol，2000，424(1)：58-73.
［27］MOHRI A，KODAMA E，KIMURA K D，et al. Genetic control of temperature preference in the nematode Caenorhabditis elegans［J］. Genetics，2005，169(3)：1437-1450.
［28］STEPHENS G J，BUENO DE MESQUITA M，RYU W S，et al. Emergence of long timescales and stereotyped behaviors in Caenorhabditis elegans［J］. Proc Natl Acad Sci U S A，2011，108(18)：7286-7289.
［29］HAAS W. Parasitic worms：strategies of host finding，recognition and invasion［J］. Zoology (Jena)，2003，106(4)：349-364.
［30］DILLMAN A R，GUILLERMIN M L，LEE J H，et al. Olfaction shapes host–parasite interactions in parasitic nematodes［J］.Proc Natl Acad Sci U S A，2012，109(35)：E2324-E2333.
［31］HAAS W，HABERL B，SYAFRUDDIN，et al. Behavioural strategies used by the hookworms Necator americanus and Ancylostoma duodenale to find，recognize and invade the human host［J］. Parasitol Res，2005，95(1)：30-39.
［32］KETSCHEK A R，FREEMAN A S，BOSTON R，et al. Vertical migratory behavior of the infective third-stage larvae of Oesophagostomum dentatum［J］.Vet Parasitol，2004，123(3-4)：215-221.
［33］CASTELLETTO M L，GANG S S，OKUBO R P，et al. Diverse host-seeking behaviors of skin-penetrating nematodes［J］.PLoS Pathog，2014，10(8)：e1004305.
［34］GRANZER M，HAAS W. Host-finding and host recognition of infective Ancylostoma caninum larvae［J］.Int J Parasitol，1991，21(4)：429-440.
［35］SCIACCA J，FORBES W M，ASHTON F T，et al. Response to carbon dioxide by the infective larvae of three species of parasitic nematodes［J］.Parasitol Int，2002，51(1)：53-62.
［36］SAFER D，BRENES M，DUNIPACE S，et al. Urocanic acid is a major chemoattractant for the skin-penetrating parasitic nematode Strongyloides stercoralis［J］.Proc Natl Acad Sci U S A，2007，104(5)：1627-1630.
［37］QIU Y T，SMALLEGANGE R C，VAN LOON J J，et al. Behavioural responses of Anopheles gambiae sensu stricto to components of human breath，sweat and urine depend on mixture composition and concentration［J］.Med Vet Entomol，2011，25(3)：247-255.
［38］SILVA B F，AMARANTE M R，KADRI S M，et al. Vertical migration of Haemonchus contortus third stage larvae on Brachiaria decumbens grass［J］.Vet Parasitol，2008，158(1-2)：85-92.
［39］ANAMNART W，INTAPAN P M，PATTANAWONGSA A，et al. Effect of dilution of stool soluble component on growth and development of Strongyloides stercoralis［J］.Sci Rep，2015，5：10749.
［40］TOBATA-KUDO H，KUDO H，TADA I. Strongyloides ratti：Chemokinesis of glycolytic enzyme- and lectin-treated third-stage infective larvae in vitro［J］.Parasitol Int，2005，54(2)：147-152.
［41］SRINIVASAN J，VON REUSS S H，BOSE N，et al. A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans［J］.PLoS Biol，2012，10(1)：e1001237.
［42］CHOE A，CHUMAN T，VON REUSS S H，et al. Sex-specific mating pheromones in the nematode Panagrellus redivivus［J］.Proc Natl Acad Sci U S A，2012，109(51)：20949-20954.
［43］CHOE A，VON REUSS S H，KOGAN D，et al. Ascaroside signaling is widely conserved among nematodes［J］.Curr Biol，2012，22(9)：772-780.
［44］PARIDA L，NEOGI S，PADMANABHAN V. Effect of temperature pre-exposure on the locomotion and chemotaxis of C. elegans［J］. PLoS One，2014，9(10)：e111342.
［45］FORBES W M，ASHTON F T，BOSTON R，et al. Chemoattraction and chemorepulsion of Strongyloides stercoralis infective larvae on a sodium chloride gradient is mediated by amphidial neuron pairs ASE and ASH，respectively［J］.Vet Parasitol，2004，120(3)：189-198.
［46］SASSA T，MURAYAMA T，MARUYAMA I N. Strongly alkaline pH avoidance mediated by ASH sensory neurons in C. elegans［J］. Neurosci Lett，2013，555：248-252.
［47］TOBATA-KUDO H，HIGO H，KOGA M，et al. Chemokinetic behavior of the infective third-stage larvae of Strongyloides ratti on a sodium chloride gradient［J］. Parasitol Int，2000，49(3)：183-188.
［48］FORBES W M，ASHTON F T，BOSTON R，et al. Chemotactic behaviour of Strongyloides stercoralis infective larvae on a sodium chloride gradient［J］. Parasitology，2003，127(Pt 2)：189-197.
［49］PATANANAN A N，BUDENHOLZER L M，ESKIN A，et al. Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans［J］. Exp Gerontol，2015，61：20-30.
［50］LI J，LI D，YANG Y，et al. Acrylamide induces locomotor defects and degeneration of dopamine neurons in Caenorhabditis elegans［J］. J Appl Toxicol，2015，36(1):60-67.
［51］DING G，ZOU W，ZHANG H，et al. In vivo tactile stimulation-evoked responses in Caenorhabditis elegans amphid sheath glia［J］. PLoS One，2015，10(2)：e0117114.
［52］ZHANG C，YAN J，CHEN Y，et al. The olfactory signal transduction for attractive odorants in Caenorhabditis elegans［J］. Biotechnol Adv，2014，32(2)：290-295.

[1]	薄禄琪, 王雪莹, 侯嘉茗, 张力, 张鉴慧, 阮入琳, 张博涵, 王爽, 宋铭忻, 张子群. siRNA-757干扰旋毛虫Ts-ODC基因对其抗酸能力的影响[J]. 畜牧兽医学报, 2023, 54(5): 2114-2125.
[2]	王冰楠, 孙雪, 贾红菓, 谭纯, 梅四鹏, 周荣琼. 犬弓首蛔虫C型凝集素4的原核表达及组织定位[J]. 畜牧兽医学报, 2023, 54(4): 1641-1651.
[3]	梁高星, 荣诗琪, 王俊伟, 李媛, 杨新, 赵光辉, 宋军科. 山羊源3种不同形态阴门盖捻转血矛线虫雌虫的多位点序列分析[J]. 畜牧兽医学报, 2022, 53(9): 3140-3148.
[4]	廖书漪, 储稳, 徐立新, 宋小凯, 李祥瑞, 严若峰. 旋毛虫重组二肽基肽酶1在体外对大鼠外周血单个核细胞增殖、吞噬、凋亡等的影响[J]. 畜牧兽医学报, 2020, 51(6): 1362-1370.
[5]	陈绍基, 李芳, 尹莎莎, 江艾耘, 周荣琼. 犬弓首蛔虫TcCPG1的表达及其与几丁质的结合特性[J]. 畜牧兽医学报, 2020, 51(2): 356-364.
[6]	罗永莉, 江艾耘, 胡志刚, 李相兰, 杨晓迪, 旷策嫣, 周荣琼. RNA干扰abcg-5基因对犬弓首蛔虫感染性的影响[J]. 畜牧兽医学报, 2019, 50(2): 390-397.
[7]	吴怡然, 古小彬, 谢跃, 杨光友. 大熊猫西氏贝蛔虫BsABF基因的原核表达及重组蛋白抗菌活性初步分析[J]. 畜牧兽医学报, 2019, 50(1): 151-158.
[8]	周丽娜, 胡孟娟, 孙伟, 李祥瑞, 徐立新, 宋小凯, 严若峰. 捻转血矛线虫脂肪酶基因表达与生物学特性分析[J]. 畜牧兽医学报, 2018, 49(3): 580-587.
[9]	王文龙, 赵学亮, 孙柯, 冯陈晨, 白丽艳, 王姝懿, 王梦雅, 刘春霞. 斯氏副柔线虫CAMK/TSSK蛋白激酶基因的克隆及其蛋白质结构与抗原表位预测分析[J]. 畜牧兽医学报, 2018, 49(3): 644-651.
[10]	廖成水, 王晓利, 田文静, 杨亚东, 张梦珂, 王安琪, 张春杰, 刘明远, Boireau Pascal, 程相朝. 旋毛虫plancitoxin-1-like基因的序列分析与编码蛋白结构预测[J]. 畜牧兽医学报, 2018, 49(1): 218-222.
[11]	吴玲燕, 王玉俭, 温玉玲, 严若峰, 徐立新, 宋小凯, 李祥瑞. 捻转血矛线虫NADH:泛醌氧化还原酶结构域包含蛋白基因的克隆表达及功能分析[J]. 畜牧兽医学报, 2017, 48(4): 722-730.
[12]	古小彬，朱俊扬，王保健，郑晶，杨光友，汪涛，赖为民. 四川地区鸡异刺线虫核糖体转录间隔区（ITS1/2）序列的遗传变异分析[J]. 畜牧兽医学报, 2016, 47(4): 796-804.
[13]	王保健，朱俊扬，简克灵，杨光友，汪涛，赖为民，赵习彬，廖晓霞，古小彬. 基于线粒体12S基因分析四川地区鸡异刺线虫的种群遗传多态性[J]. 畜牧兽医学报, 2015, 46(12): 2264-2272.
[14]	马光旭，朱宏宏，胡铃，李蔚林，林洁，周荣琼. 犬弓首蛔虫性别相关基因Tc-vit、Tc-iom、Tc-tpk、Tc-stp在不同生殖器官中的差异表达分析[J]. 畜牧兽医学报, 2015, 46(3): 461-466.